Feel Great and Detox with Glutathione
Glutathione, the “Master Antioxidant”
Glutathione is an antioxidant that plays a crucial role in maintaining cellular health and function. It's composed of three amino acids: glutamine, cysteine, and glycine. Glutathione is often referred to as the "master antioxidant" because of its ability to neutralize free radicals and protect cells from oxidative stress.
Typical Uses:
Glutathione is typically used for its antioxidant properties, which can help to:
* Reduce oxidative stress: Glutathione can help to neutralize free radicals, which can damage cells and contribute to various diseases.
* Support immune function: Glutathione is essential for the proper functioning of the immune system, and deficiencies in glutathione have been linked to impaired immune function.
* Detoxify the body: Glutathione can help to remove toxins and heavy metals from the body, which can improve overall health and well-being.
Administration:
1 . Glutathione 250 mg Troche: Dissolve one troche under the tongue daily in the morning, 15 minutes away from
food or drink
2. Glutathione 100 mg/mL Nasal Spray: Instill one spray in each nostril one to two times daily.
3. Glutathione 200 mg/mL Injectable Solution
* IM/SC: Inject 200 mg (1 mL) intramuscularly (IM) or subcutaneously (SC) one to two times weekly OR Inject 100
mg (0.5 mL) IM or SC every other day.
* IV: Infuse 500 mg in normal saline or sterile water weekly. Dose may be increased slowly and given up to twice
weekly depending on condition and desired results.
However, please note that the exact dosing may vary depending on the individual's needs and medical history.
Important Note:
It's essential to follow the recommended dosing protocol and administration instructions to ensure the best results and minimize potential side effects.
CONDITIONS THAT MAY BE ADDRESSED WITH GLUTATHIONE: 3 - 9
Individuals with conditions that are associated with oxidative stress, inflammation, and/or compromised immune function may benefit from glutathione supplementation.
* Chronic Fatigue Syndrome
* Chronic Inflammation
* Parkinson’s Disease
* Alzheimer’s Disease
* Multiple Sclerosis
* Rheumatoid Arthritis
* Inflammatory Bowel Disease
* Chronic Obstructive Pulmonary Disease (COPD)
* Asthma
* Cardiovascular Disease
* Liver Disease/Liver Detoxification of Harmful Chemicals
* Diabetes
* Improved Immune Response
* Decreased Hyperpigmentation & Improved Overall Skin Health
* Depression
* Anxiety Disorders
* Schizophrenia/Bipolar Disorders
* Prevention of Nerve Damage Due to Diabetes
* Reduce neuropathy induced by the Cancer Drug Cisplastin
* May be beneficial in individuals who engage in intense physical activity (athletes/body builders) to help to reduce muscle damage and fatigue, and support post-workout recovery.
LIMITATIONS:
* Individuals with pre-existing kidney disease should avoid high doses of glutathione.
* Individuals who are pregnant or breastfeeding should avoid glutathione as it has not been properly studied in that patient subset.
* Taking glutathione long-term has been linked to lower zinc levels.
* Inhaled glutathione may trigger asthma attacks in people who are diagnosed with asthma.
* Some patients with disease symptoms may not present with oxidative stress markers, and could be in an optimal range of redox homeostasis. Excessive glutathione supplementation in such patients might impair immune functioning.
* Glutathione may exert a limited effect in patients already on a medication regimen that harnesses anti-inflammatory pathways, such as ketamine in treatment-resistant depression.1
REFERENCES
1 . Eshkevari, Ladan, et al. “Efficacy of addition of the anti-inflammatory, IV glutathione to standard ketamine IV therapy in major depressive disorder.” Psychiatry Research 337 (2024): 115949.
2 . Bell CJM, Mehta M, Mirza L, Young AH, Beck K. Glutathione alterations in depression: a meta-analysis and systematic review of proton magnetic resonance spectroscopy studies. Psychopharmacology (Berl). 2024 Dec 21. doi: 10.1007/s00213-024-06735-1. Epub ahead of print. PMID:39708105.
3. Bounous, G., and J. Molson. “Competition for glutathione precursors between the immune system and the skeletal muscle: pathogenesis of chronic fatigue syndrome.” Medical hypotheses 53.4 (1999): 347-349.
4 . Dean OM, van den Buuse M, Bush AI, Copolov DL, Ng F, Dodd S, Berk M. A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice. Curr Med Chem. 2009;16(23):2965-76. doi: 10.2174/092986709788803060. PMID: 19689277.
5 . Fitzpatrick AM, Jones DP, Brown LA. Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2012 Jul 15;17(2):375-408. doi: 10.1089/ars.2011.4198. Epub 2012 Mar 9. PMID: 22304503; PMCID: PMC3353819.
6. Kaplowitz N. The importance and regulation of hepatic glutathione. Yale J Biol Med. 1981 Nov-Dec;54(6):497-502. PMID: 7342494; PMCID:PMC2596047.
7. Ueno, Yuki, et al. “Dietary glutathione protects rats from diabetic nephropathy and neuropathy.” The Journal of nutrition 132.5 (2002): 897-900.
8 . Bravenboer B, Kappelle AC, Hamers FP, van Buren T, Erkelens DW, Gispen WH. Potential use of glutathione for the prevention and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat. Diabetologia. 1992 Sep;35(9):813-7. doi: 10.1007/BF00399926. PMID: 1397775.
9. Tredici G, Cavaletti G, Petruccioli MG, Fabbrica D, Tedeschi M, Venturino P. Low-dose glutathione administration in the prevention of cisplatin-induced peripheral neuropathy in rats. Neurotoxicology. 1994 Fall;15
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